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KMID : 1146920180480030409
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Journal of Pharmaceutical Investigation
2018 Volume.48 No. 3 p.409 ~ p.419
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Solvent effect on fluid characteristics of doxycycline hyclate-loaded bleached shellac in situ-forming gel and -microparticle formulations
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Phaechamud Thawatchai
Praphanwittaya Pitsiree
Laotaweesub Kunchalee
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Abstract
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This research purposed to better comprehend the behavior of solvent including dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP) and 2-pyrrolidone (PYR) in bleached shellac solution from preparation process of in situ forming gel (isg) and microparticle (ism). Doxycycline hyclate-loaded bleached shellac isg was used as the internal phase of oil in oil emulsion of ism. Fluid characteristics including pH, density, relative viscosity and surface/interfacial tension, droplet size of emulsion, phase separation rate and apparent viscosity were determined. Bleached shellac dissolved in these solvents via strongly hydrogen bonding and van der Wall forces. In the case of ism systems, the trend of viscosity was similar with isg but their viscosity was lower because of the presence of oil in the external phase. PYR formula were the most viscous whereas those prepared with NMP were contrary therefore PYR could interact with bleached shellac molecule less than NMP. The solubility parameter, interfacial tension, apparent and relative viscosities confirmed that NMP was a good solvent for this resin. However, NMP exhibited a partial miscible with oil; thus, generated a rapid phase separation. Therefore DMSO and PYR could use as the solvents to fabricate into the o/o emulsion of ism with a suitable manner for local injection owing to their newtonian or pseudoplastic flows. These results will be useful for future investigation of physicochemical characteristics of obtained gel or microparticle and also their solvent exchange and drug release behavior.
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KEYWORD
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Fluid characteristic, Solvent, Doxycycline hyclate, Bleached shellac, In situ-forming gel, In situ-forming microparticle
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